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    2018-8-31 · cation and guidance of doxycycline hydrochlo-ride with sufficient pharmacokinetic parame-ters and rational theoretical basis. Materials and methods Materials Standard doxycycline hydrochloride with 85.2% purity was obtained from China Institute of Veterinary Drug Control (IVDC, Beijing). Original powder of doxycycline hydrochloride with 83.6%

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