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  • Efficacy and Safety of Single and Double Doses of ...

    2011-5-10 · This study confirms that both a single, and a double dose of oral ivermectin taken two weeks apart, is more effective than a 7-day course of high dose albendazole for patients with chronic infection due to S. stercoralis. Double dose of ivermectin, taken two weeks apart, might be more effective than a single dose in patients with concomitant illness.

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  • Assessment of Efficacy and Quality of Two

    2015-9-25 · These trials showed that the therapeutic efficacy measured in terms of egg reduction rate (ERR), varied both between drugs and STH species: both drugs showing high efficacy against A. lumbricoides (> 98%) and poor efficacy against T. trichiura (~64%), and ABZ being more efficacious against hookworms compared to mebendazole (96% vs. 80%).

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  • Efficacy and Safety of Nitazoxanide, Albendazole, and ...

    2012-6-5 · Nonetheless, these data illustrate that the standard treatment albendazole has a high efficacy against these parasites. The good activity against these two helminths and low efficacy against T. trichiura is also supported by the baseline prevalences (T. trichiura (82.2%), hookworm (6.8%), and A. lumbricoides (4.6%)) observed in the current trial. The settings where the study was conducted (Wawi …

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  • Safety and efficacy of co-administered

    2020-6-8 · Several clinical trials have shown that a single oral dose of ivermectin (IVM), diethylcarbamazine (DEC) and albendazole (ALB) (IDA) is more effective than DEC plus ALB (DA) for clearing Wuchereria bancrofti microfilariae (Mf). We performed a cluster-randomized community study to compare the safety and efficacy of IDA and DA in an LF-endemic area in northern Haiti.

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  • Efficacy and Safety of Anthelmintics Tested against

    2013-7-25 · Albendazole, another BZ anthelmintic, is oxidized to albendazole sulphoxide, the systematically active metabolite, and then further oxidized to albendazole sulphone, which is inactive . It is a broad-spectrum anthelmintic that is effective against nematode, trematode, and cestode infections in sheep and cattle at a dose between 5–10 mg/kg [6] , [15] .

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  • Efficacy of Albendazole-Chitosan Microsphere-based ...

    2015-9-9 · Chitosan microspheres as a new carrier increased ABZ absorption and bioavailability. The anti-parasitic efficacy of albendazole–chitosan microspheres (ABZ-CS-MPs) in mice infected with Echinococcus multilocularis was assessed. ABZ-loaded CS-MPs exhibited improved absorption and increased bioavailability in the treatment of E.

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  • Low Efficacy of Single-Dose Albendazole and

    2012-1-3 · Both drugs showed a similar profile, with low efficacy against hookworm and, additionally, low efficacy against T. trichiura, and high efficacy against A. lumbricoides. The low efficacy of single-dose of albendazole against hookworm should be followed-up closely and further investigated as this drug is widely used for preventive chemotherapy against STHs and in combination with ivermectin in the …

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  • The Effect of Deworming Using Triple-Dose

    2017-11-8 · Keiser and Utzinger stated that the efficacy of albendazole is higher compared to mebendazole, except for T. trichiura. Aside from decreasing the prevalence, triple dose of albendazole is also able to reduce the intensity of infection which has a …

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  • Single Dose of Albendazole in the Treatment of

    1990-3-1 · The syndrome of cutaneous larva migrans, also known as creeping eruption, is a process commonly found in inhabitants of tropical or subtropical regions of the world. It is caused by penetration of the skin by infective larvae of hookworms from various animals.

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  • Prophylactic efficacy of clorsulon against Fasciola ...

    1985-6-1 · A daily oral 5 mg kg −1 dose of clorsulon for 28 days in calves given Fasciola hepatica cryts at 3, 5, and 7 days after initiation of treatment was highly effective in reducing worm burdens (98%) and preventing liver pathology. In similarly infected and treated sheep, clorsulon showed little effect as a prophylactic for delaying the onset of liver pathology The size of flukes recovered from treated sheep …

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  • (PDF) High efficacy of albendazole-PEG 6000 in the ...

    High efficacy of albendazole-PEG 6000 in the treatment of Toxocara canis larva migrans infection. ... because it is the rate-limiting process in the absorption of these humans and animals.1 In humans, Toxocara canis infection may compounds after oral administration. ... by uninfected and infected mice regardless of the dose administered. There ...

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  • Efficacy and safety of albendazole plus ivermectin ...

    2015-3-1 · Albendazole plus ivermectin, and albendazole plus oxantel pamoate had greater efficacy against T trichiura compared with the established standard treatment of one-dose mebendazole. Albendazole plus oxantel pamoate showed the greatest efficacy in this study, confirming its promising anthelmintic potential shown in our predecessor trial (see panel).

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  • Safety and efficacy of co-administered

    2020-6-8 · Edi C, Bjerum CM, Ouattara AF, Chhonker YS, Penali LK, Meite A, et al. Pharmacokinetics, safety, and efficacy of a single co-administered dose of diethylcarbamazine, albendazole and ivermectin in adults with and without Wuchereria bancrofti infection in Cote d'Ivoire.

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  • A meta-analysis of the efficacy of albendazole

    2016-1-1 · A recent systematic review by Pasupuleti et al., (2014), including 30 RCTs (n = 3930), published up to 2014, that evaluated the efficacy of 5-NI drugs, found that TNZ was the most effective single-dose therapy compared with other short therapies, having at …

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  • Efficacy and safety of ivermectin and albendazole co ...

    2019-3-18 · Soil-transmitted helminthiasis affects almost 2 billion people worldwide in tropical climates. Preventive chemotherapy, using the benzimidazoles (albendazole and mebendazole) is the current main recommended control strategy. Nevertheless, there is limited efficacy of these drugs against hookworm infection and, to a greater extent, against trichuriasis.

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  • Comparison of Efficacy and Side Effect Between

    2017-9-30 · 3. Steinmann P, Utzinger J, Du Z–W, Jiang J-Y, Chen J-X,et at. Efficacy of singel-dose and triple-dose albendazole and mebendazole against soil-transmitted helminths and taenia spp.; A randomized controlled trial. Plos ONE 6 (9); e25003. 2011. 4. WHO.

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  • (PDF) Efficacy of a single dose albendazole

    Efficacy of a single dose albendazole chemotherapy on human intestinal helminthiasis among school children in selected rural tropical communities. Joseph Eyo. Related Papers. Effects of Annual Mass Treatment with Ivermectin for Onchocerciasis on the Prevalence of Intestinal Helminths.

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  • Single Dose of Albendazole in the Treatment of

    To the Editor.— The syndrome of cutaneous larva migrans, also known as creeping eruption, is a process commonly found in inhabitants of tropical or subtropical regions of the world. It is caused by penetration of the skin by infective larvae of hookworms from various animals. Ancylostoma braziliense, a hookworm of cats and dogs, causes most cases, although other nematodes, including ...

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  • Efficacy and Safety of Anthelmintics Tested against

    2013-7-25 · Albendazole sulphoxide is available for use in ruminants for control of intestinal nematodes and some trematodes and cestodes at doses between 5–7.5 mg/kg . It is not registered for use in pigs. The efficacy of ABZSO against porcine cysticercosis was evaluated in Mexico . Seven naturally infected pigs (four sows and two boars) with age ...

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  • The Effect of Deworming Using Triple-Dose

    2017-11-8 · High prevalence of STH leads to malnutrition, anemia, cognitive impairment, and growth disorders. Triple-dose albendazole 400 mg is a broad-spectrum anthelminthic; however, its effectiveness varies in every region. This study aims to determine the benefits of deworming using triple-dose albendazole on children’s nutritional status in Perobatang Village, Southwest Sumba, Indonesia.

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  • Efficacy of High-Dose Albendazole with Ivermectin for ...

    2019-7-2 · F. Gobbi et al. Welcome! Log into your account. your username

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  • Holdings: Efficacy of High-Dose Albendazole with ...

    Efficacy of High-Dose Albendazole with Ivermectin for Treating Imported Loiasis, Italy . We describe the outcomes of 16 cases of imported loiasis in Italy. Patients had microfilaremia <20,000/mL and were treated with high-dose albendazole for 28 days and a single dose of ivermectin.

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  • Comparison of Efficacy and Side Effect Between

    2017-9-30 · 3. Steinmann P, Utzinger J, Du Z–W, Jiang J-Y, Chen J-X,et at. Efficacy of singel-dose and triple-dose albendazole and mebendazole against soil-transmitted helminths and taenia spp.; A randomized controlled trial. Plos ONE 6 (9); e25003. 2011. 4. WHO.

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  • Efficacy and safety of albendazole plus ivermectin ...

    2015-3-1 · Albendazole plus ivermectin, and albendazole plus oxantel pamoate had greater efficacy against T trichiura compared with the established standard treatment of one-dose mebendazole. Albendazole plus oxantel pamoate showed the greatest efficacy in this study, confirming its promising anthelmintic potential shown in our predecessor trial (see panel).

    Get Price
  • Efficacy and safety of ivermectin and albendazole co ...

    2019-3-18 · Soil-transmitted helminthiasis affects almost 2 billion people worldwide in tropical climates. Preventive chemotherapy, using the benzimidazoles (albendazole and mebendazole) is the current main recommended control strategy. Nevertheless, there is limited efficacy of these drugs against hookworm infection and, to a greater extent, against trichuriasis.

    Get Price
  • A meta-analysis of the efficacy of albendazole

    2016-1-1 · A recent systematic review by Pasupuleti et al., (2014), including 30 RCTs (n = 3930), published up to 2014, that evaluated the efficacy of 5-NI drugs, found that TNZ was the most effective single-dose therapy compared with other short therapies, having at …

    Get Price
  • Efficacy of Current Drugs Against Soil-Transmitted ...

    Albendazole may be beneficial for the early as well as the later-stage infection, although further investigation is needed to establish a time frame for albendazole efficacy. This in vitro study, for the first time, provides tangible evidence by actually quantifying the larvicidal activity of albendazole on the A. cantonensis infectious L3.

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  • In vitro efficacy of anthelmintics on Angiostrongylus ...

    2018-4-16 · The L4 stage worms of N2, DA1316, and CB3474 were incubated at a lethal dose of ivermectin (100 ng/mL) and albendazole (100 µg/mL) for 24 h. The DA1316 and CB3474 worms were resistant to ivermectin and albendazole respectively, while all the wild type worms exposed to ivermectin and albendazole died at this concentration (data not shown).

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  • Anthelmintic efficacy of glycolipid biosurfactant

    Efficacy of a single dose albendazole chemotherapy on human intestinal helminthiasis among school children in selected rural tropical communities. Joseph Eyo. Related Papers. Effects of Annual Mass Treatment with Ivermectin for Onchocerciasis on the Prevalence of Intestinal Helminths.

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  • Efficacy and safety of albendazole plus ivermectin ...

    2015-1-11 · Albendazole plus ivermectin, and albendazole plus oxantel pamoate had greater efficacy against T trichiura compared with the established standard treatment of one-dose mebendazole. Albendazole plus oxantel pamoate showed the greatest efficacy in this study, confirming its promising anthelmintic potential shown in our predecessor trial (see panel ).

    Get Price
  • Comparative study of the quality and efficacy of ...

    2007-5-1 · A community-based, randomised, single-blind trial on the efficacy of generic and originator ABZ was conducted. The study was carried out among primary school-age children in Nepal. The rural region of Syangja was selected for its known high prevalence of STH infections, relatively good accessibility of surrounding villages and security reasons.

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  • Monitoring of drug efficacy in large scale treatment ...

    2008-6-15 · An adequate response to this new challenge was urgently needed. A meeting on 'Monitoring of drug efficacy in large scale treatment programmes in human helminthiasis', jointly organized by WHO and the World Bank, took place in Washington, DC at the World Bank Headquarters from 31 October to 2 November 2007, with the aim of addressing the issue ...

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  • Albendazole in treatment of human cystic

    1997-4-1 · The ratio of males to females is almost equal in all data sets. Age ranges quoted in publications ranged from 3.5 years (Wen et al., 1994b; Singh and Garg, 1992) to 94 years (Nahmias et al., 1994) with the average age of the populations in the 5th decade.In terms of sex ratio and age range therefore the population is typical for cystic echinococcosis with relatively few young children ...

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  • Different Drugs in Treating Urinary Schistosomiasis ...

    A comparative study on the efficacy of praziquantel and albendazole in the treatment of urinary schistosomiasis in Adim, Cross River State, Nigeria. Int Heal. 2017;9: 288-293. Groning E, Bakathir H, Salem A, Albert L, Fernández R. Effectiveness and tolerance of praziquantel in schistosomiasis.

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  • Albendazole-induced granulomatous hepatitis: a case

    2013-7-26 · Singthong S, Intapan PM, Wongsaroji T, Maleewong W: Randomized comparative trial of two high-dose albendazole regimens for uncomplicated human strongyloidiasis. Southeast Asian J Trop Med Public Health. 2006, 37 (Suppl 3): 32-34. CAS PubMed Google Scholar 9.

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  • Immunotherapy Can Enhance Anthelmintic Efficacy in ...

    The OXF dose of 30 mg/kg was selected on the basis of its efficacy against Taenia solium cysticercosis in pigs 13 and treatment of sheep for hydatid cysts. 4, 14 However, the 15 mg/kg BW dose of NTZ was selected on the basis of the highest described nontoxic dose used in humans 18 – 20 and a trial performed in pigs.

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  • Evaluation of Nitazoxanide and Oxfendazole Efficacy ...

    Albendazole sulphoxide (ABZSO) Albendazole sulphoxide is available for use in ruminants for control of intestinal nematodes and some trematodes and cestodes at doses between 57.5 mg/kg [6]. It is not registered for use in pigs. The efficacy of ABZSO against porcine cysticercosis was …

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  • Efficacy and Safety of Anthelmintics Tested against

    2009-6-27 · Albendazole and mebendazole are benzimidazoles used for the therapy of various helminthic infections as well as for the treatment of hydatid disease (Echinococcus granulosus) and alveolar echinococcosis (Echinococcus multilocularis) [].The combination of benzimidazoles with anti-HIV medications such as protease inhibitors is increasingly used in developing countries, where both …

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  • Efficacy and safety of albendazole plus ivermectin ...

    2015-1-11 · Albendazole plus ivermectin, and albendazole plus oxantel pamoate had greater efficacy against T trichiura compared with the established standard treatment of one-dose mebendazole. Albendazole plus oxantel pamoate showed the greatest efficacy in this study, confirming its promising anthelmintic potential shown in our predecessor trial (see panel ).

    Get Price
  • Different Drugs in Treating Urinary Schistosomiasis ...

    A comparative study on the efficacy of praziquantel and albendazole in the treatment of urinary schistosomiasis in Adim, Cross River State, Nigeria. Int Heal. 2017;9: 288-293. Groning E, Bakathir H, Salem A, Albert L, Fernández R. Effectiveness and tolerance of praziquantel in schistosomiasis.

    Get Price
  • Monitoring of drug efficacy in large scale treatment ...

    The OXF dose of 30 mg/kg was selected on the basis of its efficacy against Taenia solium cysticercosis in pigs 13 and treatment of sheep for hydatid cysts. 4, 14 However, the 15 mg/kg BW dose of NTZ was selected on the basis of the highest described nontoxic dose used in humans 18 – 20 and a trial performed in pigs.

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  • Evaluation of Nitazoxanide and Oxfendazole Efficacy ...

    2015-4-15 · The twice-yearly high dose albendazole (800 mg dose) and ivermectin (400 µg/kg) treatment regimen had a non-significant tendency to faster clearance of microfilaraemia compared to the WHO-recommended annual standard dose albendazole 400 mg single dose and ivermectin 200 µg/kg treatment regimen, without any increase in adverse events.

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  • Randomised controlled clinical trial of increased dose

    2012-10-1 · At a higher single oral dose (5–10 mg/kg), FBZ exhibits a high efficacy against most important GI nematodes in pigs, except Trichuris suis (Biehl, 1986). The OFZ plasma disposition kinetics administered at 30 mg/kg as a single oral dose to pigs is reported for the first time in the present work. None of the animals involved in the current ...

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  • A high oxfendazole dose to control porcine

    2013-7-26 · Singthong S, Intapan PM, Wongsaroji T, Maleewong W: Randomized comparative trial of two high-dose albendazole regimens for uncomplicated human strongyloidiasis. Southeast Asian J Trop Med Public Health. 2006, 37 (Suppl 3): 32-34. CAS PubMed Google Scholar 9.

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  • Albendazole-induced granulomatous hepatitis: a case

    Albendazole sulphoxide (ABZSO) Albendazole sulphoxide is available for use in ruminants for control of intestinal nematodes and some trematodes and cestodes at doses between 57.5 mg/kg [6]. It is not registered for use in pigs. The efficacy of ABZSO against porcine cysticercosis was …

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  • Efficacy and Safety of Anthelmintics Tested against

    Malaria Eradication Scientific Alliance (MESA) and US Centers for Disease Control and Prevention (CDC).

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  • Safety and mosquitocidal efficacy of high-dose

    2018-6-1 · Adverse events were mild and transient. Praziquantel revealed dose-independent efficacy against light infections of S. haematobium. Over the dose range tested, praziquantel displayed a ceiling effect with the highest response for 20 mg/kg in PSAC. In SAC maximum efficacy was obtained with 40 mg/kg praziquantel.

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  • Safety and mosquitocidal efficacy of high-dose

    Malaria Eradication Scientific Alliance (MESA) and US Centers for Disease Control and Prevention (CDC).

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  • The efficacy of high-dose penicillin G for

    High-dose penicillin therapy is effective in approximately 90% of pneumococcal pneumonia cases diagnosed based on urinary pneumococcal antigen tests or Gram staining at admission. The efficacy of high-dose penicillin therapy for pneumococcal pneumonia diagnosed based on an initial comprehensive assessment comprising a syndromic approach, Gram staining of sputum and urinary pneumococcal …

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  • Clinical efficacy of high-dose dexamethasone with ...

    2021-4-13 · ObjectiveAs first-line treatments for newly diagnosed adult immune thrombocytopenia (ITP), high-dose dexamethasone (HD-DXM) and conventional-dose …

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  • Comparative study of the quality and efficacy of ...

    2007-5-1 · Summary. The quality and efficacy of two locally manufactured generic albendazole (ABZ) products (Curex and Royal Drug) used for deworming children in Nepal sin

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  • Efficacy of High-dose Chemotherapy and Autologous

    2019-5-31 · n individual patient data meta-analysis on 100 patients collected from 6 studies to determine characteristics that predict survival in relapsed patients who received ASCR therapy. We compare these results with survival data on 118 CT treated patients from 2 recently published studies. Four year overall survival among the combined ASCR treated patients was 54.1% (95% CI: 42.8-64.1%). The ASCR ...

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  • Efficacy of High Dose Atorvastatin Loading in ST

    Although statin prior to PCI has favorable effects in stable angina and ACS except ST elevation MI (STEMI), there have been few studies for STEMI. Celik T et

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  • Efficacy of High-Dose Methotrexate in Pediatric Non ...

    2019-11-12 · dose group (median 35.2, IQR 20.5 – 72.1 months) was significantly longer than in the high dose group (median 16.6, IQR 7.8 – 22.5 months) (p= 0.01). No statistically significant differences in ocular complications, steroid-sparing effect, cumulative dosage and side effects of MTX were found between the high and low dose groups.

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  • Long-term safety and efficacy of high-dose controlled ...

    High-dose calcium channel blocker (CCB) shows strong blood pressure (BP) lowering effect. Currently available of controlled-release (CR) nifedipine 80 mg per day clinical data are limited to ...

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  • Safety and Efficacy of High Dose Bowel Preparation ...

    Safety and Efficacy of High Dose Bowel Preparation Solutions for Patients With Difficult To Clean Colons For Colonoscopy Brief description of study The purpose of this study is to document the safety and effectiveness of high doses of liquids to clean the colon for colonoscopy in patients who had a previous colonoscopy with a poorly cleaned colon.

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  • Effect of Genotype and Sex of the Host on the ...

    2020-5-20 · Albendazole (ABZ), an anthelmintic compound widely used in the treatment of systemic nematode infections, is included in the list of class II drugs based on the Biopharmaceutical Classification System. ABZ has limited effectiveness due to its poor water solubility and consequent low bioavailability. Bioavailability of novel ABZ microcrystals based on hydroxyethylcellulose (S4A) or chitosan ...

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  • ed ic n c a l M Sur p i g o er T y Tropical Medicine and ...

    2021-4-1 · efficacy in treating SH infection [5-15]. Praziquantel (PZQ) is the most used drug worldwide and is the drug of choice for controlling schistosomiasis in endemic regions [16]. The reasons for that is its efficacy in reducing egg count at a relatively high rate across different types of …

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  • Diagnosis and Treatment of Neurocysticercosis: 2017 ...

    2018-2-22 · Among those with 3 or more cysticerci, on MRI at 180 days of follow-up, resolution of all viable cysts was demonstrated in 13 of 19 (68%) in the combination group compared to 1 of 21 (5%) in the standard-dose albendazole group and 5 of 20 (25%) in the high-dose albendazole group (P < …

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  • Benzimidazoles - Pharmacology - Merck Veterinary

    An albendazole slow-release capsule has been marketed in Europe and Australasia for small ruminants. This device contains 3.85 g of albendazole and delivers a daily dose of 36.7 mg for 105 days. It is an efficient device to control benzimidazole-susceptible nematodes.

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  • (PDF) In vivo evaluation of albendazole microspheres

    Albendazole is a benzimidazole derivative with proven efficacy against many parasites such as intestinal helminths. Toxocariasis is one of the important parasitic diseases in humans and animals caused by Toxocara canis. It is well known that T. canis

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  • How to Identify Critical Quality Attributes and Critical ...

    2015-10-1 · Once potentially high risk variables are identified: Identify levels or ranges of these potentially high risk attributes and/or parameters. Design and conduct experiments, using DOE when appropriate. Analyze the experimental data to determine if a material attribute or process parameter is critical.

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  • Safety and Efficacy of the BNT162b2 mRNA Covid-19

    2020-12-10 · A two-dose regimen of BNT162b2 (30 μg per dose, given 21 days apart) was found to be safe and 95% effective against Covid-19. The vaccine met both primary efficacy …

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  • Dosage and Form of Herbs: Decoctions, Dried

    2017-10-10 · Dosage form. If an herb contains 5% of an active component, and an effective dose is 500 mg of active component, then one has to ingest 10 grams of the herb (or use even more in an inefficient decoction process); if the component is made pure, then the desired 500 mg dose will fit into a single capsule or tablet. Concerns about other components.

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  • The therapeutic potential of microdosing psychedelics

    2020-8-27 · The control group entered an open-label crossover to 200 mcg LSD after the treatment blind was broken. The number, frequency and intensity of drug-related adverse events was higher in the high dose condition compared with the low dose condition, though anger, anxiety, and abnormal thinking were more frequent in the low dose condition.

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  • High-Dosage Tutoring Is Effective, But Expensive.

    2020-8-19 · The research on high-dosage tutoring —generally defined as one-on-one tutoring or tutoring in very small groups at least three times a week, or for about 50 hours over a semester—is robust ...

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  • Benzimidazoles - Pharmacology - Merck Veterinary

    An albendazole slow-release capsule has been marketed in Europe and Australasia for small ruminants. This device contains 3.85 g of albendazole and delivers a daily dose of 36.7 mg for 105 days. It is an efficient device to control benzimidazole-susceptible nematodes.

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  • Program: Mass Administration of Albendazole and

    2021-6-18 · In a nutshell The Problem: Lymphatic filariasis can cause severe debilitation (including disfiguration of limbs through elephantiasis) that can lead to an inability to work and societal discrimination. The Program: Mass drug administration (MDA) of ivermectin and albendazole for all members of the population, aiming to eliminate lymphatic filariasis from endemic areas.

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  • Treatment of soil-transmitted helminth infections in ...

    Twenty-three studies were included. Gestational treatment with albendazole had cure rates up to 90% for hookworm and Ascaris, but only 50% for Trichuris.Mebendazole had an overall cure rate of ≤ 70% for Ascaris, hookworm and Trichuris.Pooled relative risk reduction of hookworm prevalence at delivery with albendazole compared to placebo was 90% (95% confidence interval, 0.09–0.15; n = 2; I ...

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  • The Moderna COVID-19 (mRNA-1273) vaccine: what

    2021-1-26 · The Moderna vaccine has been shown to have an efficacy of approximately 94.1 per cent in protecting against COVID-19, starting 14 days after the first dose. Does it work against new variants? Based on the evidence so far, the new variants of SARS-CoV-2, including the B.1.1.7 and the 501Y.V2, do not alter the effectiveness of the Moderna mRNA ...

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  • Safety and Efficacy of the BNT162b2 mRNA Covid-19

    2020-12-10 · A two-dose regimen of BNT162b2 (30 μg per dose, given 21 days apart) was found to be safe and 95% effective against Covid-19. The vaccine met both primary efficacy …

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  • Sanofi Flu

    2021-4-1 · According to a head-to-head randomized controlled efficacy trial among adults 65+ years of age, FLUZONE HIGH-DOSE (INFLUENZA VACCINE) provided 24% (95%, CI: 10-37) better protection against influenza due to lab-confirmed circulating strain compared with standard-dose Fluzone (Influenza vaccine). 1,3,a Based on data from Fluzone High-Dose, solicited injection site reactions and systemic …

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  • How to Identify Critical Quality Attributes and Critical ...

    2015-10-1 · Once potentially high risk variables are identified: Identify levels or ranges of these potentially high risk attributes and/or parameters. Design and conduct experiments, using DOE when appropriate. Analyze the experimental data to determine if a material attribute or process parameter is critical.

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  • John P. Moore: How do you take your vaccine—one

    Key Points. Question Do atropine, 0.01%, eyedrops slow the myopia progression and axial elongation when compared with a placebo group in Chinese children?. Findings In this randomized clinical trial, atropine, 0.01%, eyedrops reduced myopia progression and axial elongation compared with placebo treatment after 1 year.. Meaning While the clinical relevance of the results cannot be determined ...

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  • Overseas Refugee Health Guidance | Immigrant and ...

    High-dose albendazole (400 mg twice a day for 7 days) is an acceptable alternative and is considered safe in Loa loa infected people, if Loa loa infection cannot be excluded. Schistosomiasis. Refugees from sub-Saharan Africa should also receive presumptive pre-departure therapy with praziquantel for schistosomiasis .

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  • The FDA's Drug Review Process: Ensuring Drugs Are

    2021-6-23 · In accordance with the Prescription Drug User Fee Act (PDUFA), the FDA's Center for Drug Evaluation and Research (CDER) expects to review and act …

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  • Overview of Vaccine Efficacy and Vaccine Effectiveness

    Vaccine effectiveness- ability of vaccine to prevent outcomes of interest in the “real world” Primary care settings Less stringent eligibility Assessment of relevant health outcomes Clinically relevant treatment selection and follow- up duration Assessment of relevant adverse events Adequate sample size to detect clinically relevant

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  • Evaluation of Oxfendazole, Praziquantel and

    The longest trial used OXF at 30 mg/Kg for eleven consecutive weeks [24] while the other two used OXF at 30 mg/Kg twice a week for four weeks [25,32]; all of them achieved high efficacy against CE (,90%). In our trial, we increased the OXF dose (60 mg/Kg), and for …

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  • WHO lists two additional COVID-19 vaccines for

    2021-2-15 · The WHO prequalification process will assess additional clinical data generated from vaccine trials and deployment on a rolling basis to ensure the vaccine meets the necessary standards of quality, safety and efficacy for broader availability. WHO also listed the Pfizer/BioNTech vaccine for emergency use on 31 December 2020. Listings

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  • Therapy for Neurocysticercosis: Comparison Between ...

    Albendazole and praziquantel were effective when compared with the control group. However, albendazole was significantly more effective than praziquantel in reducing the total number of cysts in the computed tomographic scans (88% vs 50%). Despite these results, however, analysis of clinical course showed a high frequency of neurologic sequelae.

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  • Benefits of peer support groups in the treatment of

    2016-9-29 · Self-efficacy was significantly increased in the experimental condition, and post-intervention self-efficacy was a positive mediator between the intervention and distributive risk behaviors. In the study previously discussed in the substance use section, Velasquez et al 71 also found a reduction in the number of days on which both heavy ...

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  • John P. Moore: How do you take your vaccine—one

    Efficacy definition is - the power to produce an effect. How to use efficacy in a sentence.

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  • Overseas Refugee Health Guidance | Immigrant and ...

    High-dose albendazole (400 mg twice a day for 7 days) is an acceptable alternative and is considered safe in Loa loa infected people, if Loa loa infection cannot be excluded. Schistosomiasis. Refugees from sub-Saharan Africa should also receive presumptive pre-departure therapy with praziquantel for schistosomiasis .

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  • NIH Public Access Yan Hu, and Raffi V. Aroian Section of ...

    2016-1-8 · combines synergistically with other classes of anthelmintic drugs, i.e. albendazole and pyrantel, making it a good candidate for further studies on its use in drug combination therapy of STH infections. Given NTZ acts against a wide range of nematode parasites, our findings also validate avr-14 as an excellent target for pan-STH therapy. 1 ...

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  • Evaluation of Oxfendazole, Praziquantel and

    The longest trial used OXF at 30 mg/Kg for eleven consecutive weeks [24] while the other two used OXF at 30 mg/Kg twice a week for four weeks [25,32]; all of them achieved high efficacy against CE (,90%). In our trial, we increased the OXF dose (60 mg/Kg), and for …

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  • Comparative in vitro efficacy of kefir produced from

    The burden of influenza in Africa is substantial and underappreciated. Although surveillance has increased, the medical community's understanding of seasonal influenza vaccine performance remains limited. We did a systematic review, using PRISMA guidelines (PROSPERO CRD42017058107), on the efficacy, effectiveness, and immunogenicity of influenza vaccines in populations within Africa with the ...

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  • Mebendazole: an Over-the-Counter Anti-Parasite

    Imunomodulative effect of liposomized muramyltripeptide phosphatidylethanolamine (L-MTP-PE) on mice with alveolar echinococcosis and treated with albendazole Parasitology Research, 2008 Peter Fedoročko

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  • The efficacy, effectiveness, and immunogenicity of ...

    2018-7-31 · Steinmann P, Utzinger J, Du ZW, et al. Efficacy of single-dose and triple-dose albendazole and mebendazole against soil-transmitted helminths and Taenia spp.: a randomized controlled trial. PLoS One. 2011. 6(9):e25003. . .

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  • (PDF) Imunomodulative effect of liposomized ...

    2016-10-24 · Severe acute malnutrition (SAM) affects almost all organs and has been associated with reduced intestinal absorption of medicines. However, very limited information is available on the pharmacokinetic properties of antimalarial drugs in this vulnerable population. We assessed artemether-lumefantrine (AL) clinical efficacy in children with SAM compared to those without.

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